The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6.


Interleukin (IL)-11 is a multifunctional member of the IL-6 family of cytokines. Recombinant human IL-11 is administered as a standard clinical treatment for chemotherapy-induced thrombocytopaenia. Recently, a new role for IL-11 signalling as a potent driver of gastrointestinal cancers has been identified, and it has been demonstrated to be a novel… (More)
DOI: 10.1107/S1399004714012267