The structure of human complement component C7 and the C5b-7 complex.

  title={The structure of human complement component C7 and the C5b-7 complex.},
  author={Richard G. Discipio and Deb N. Chakravarti and HANs J. MULLER-EBERHARD and Georg H. Fey},
  journal={The Journal of biological chemistry},
  volume={263 1},
The molecular architecture of human complement component C7 was elucidated at several structural levels. The complete primary structure of C7 was derived from the cDNA sequence of clones isolated from a human liver library. C7 is a mosaic protein that consists of 821 amino acids. The amino-terminal two-thirds of C7 has 23-30% homology with complement components C8 and C9. In addition, the carboxyl-terminal third contains four cysteine-rich segments that have overlapping internal homology. The… CONTINUE READING
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