The structure of foot-and-mouth disease virus.


Structural studies of foot-and-mouth disease virus (FMDV) have largely focused on the mature viral particle, providing atomic resolution images of the spherical protein capsid for a number of sero- and sub-types, structures of the highly immunogenic surface loop, Fab and GAG receptor complexes. Additionally, structures are available for a few non-structural proteins. The chapter reviews our current structural knowledge and its impact on our understanding of the virus life cycle proceeding from the mature virus through immune evasion/inactivation, cell-receptor binding and replication and alludes to future structural targets.


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@article{Fry2005TheSO, title={The structure of foot-and-mouth disease virus.}, author={Elizabeth E. Fry and David I Stuart and Daniel J. Rowlands}, journal={Current topics in microbiology and immunology}, year={2005}, volume={288}, pages={71-101} }