The structure of docking domains in modular polyketide synthases.

@article{Broadhurst2003TheSO,
  title={The structure of docking domains in modular polyketide synthases.},
  author={R. William Broadhurst and Daniel Nietlispach and Michael P Wheatcroft and Peter Francis Leadlay and Kira J Weissman},
  journal={Chemistry & biology},
  year={2003},
  volume={10 8},
  pages={723-31}
}
Polyketides from actinomycete bacteria provide the basis for many valuable medicines, so engineering genes for their biosynthesis to produce variant molecules holds promise for drug discovery. The modular polyketide synthases are particularly amenable to this approach, because each cycle of chain extension is catalyzed by a different module of enzymes, and the modules are arranged within giant multienzyme subunits in the order in which they act. Protein-protein interactions between terminal… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Intermodular The coordinates for the A and B domains of the Dock 2-3 protein

  • P. Kumar, Q. Li, D. E. Cane, C. Khosla
  • 2003

4 , 22 – 27 . to DNA

  • T. M. Laue, B. D. Shah, T. M. Ridgeway, S. Y. Tsuji, D. E. Cane, C. Khosla
  • Nature
  • 2001

Similar Papers

Loading similar papers…