The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation.

@article{Cendron2007TheSO,
  title={The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation.},
  author={Laura Cendron and Rodolfo Berni and Claudia Folli and Ileana Ramazzina and Riccardo Percudani and Giuseppe Zanotti},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 25},
  pages={18182-9}
}
The complete degradation of uric acid to (S)-allantoin, as recently elucidated, involves three enzymatic reactions. Inactivation by pseudogenization of the genes of the pathway occurred during hominoid evolution, resulting in a high concentration of urate in the blood and susceptibility to gout. Here, we describe the 1.8A resolution crystal structure of the homodimeric 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, which catalyzes the last step in the urate degradation pathway… CONTINUE READING