• Biology, Medicine
• Published in
  American journal of human…
  2007
• DOI:10.1086/522239

The structure of common genetic variation in United States populations.

@article{Guthery2007TheSO,
  title={The structure of common genetic variation in United States populations.},
  author={Stephen L Guthery and Benjamin A. Salisbury and Manish S. Pungliya and J. Claiborne Stephens and Michael Bamshad},
  journal={American journal of human genetics},
  year={2007},
  volume={81 6},
  pages={
          1221-31
        }
}

• Stephen L Guthery, Benjamin A. Salisbury, +2 authors Michael Bamshad

The common-variant/common-disease model predicts that most risk alleles underlying complex health-related traits are common and, therefore, old and found in multiple populations, rather than being rare or population specific. Accordingly, there is widespread interest in assessing the population structure of common alleles. However, such assessments have been confounded by analysis of data sets with bias toward ascertainment of common alleles (e.g., HapMap and Perlegen) or in which a relatively… CONTINUE READING

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