The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion.

@article{Ringwald1987TheSO,
  title={The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion.},
  author={M. Ringwald and Reinhard Schuh and Dietmar Vestweber and Harald Eistetter and Friedrich Lottspeich and J{\"u}rgen Engel and Reinhard D{\"o}lz and Fritz J{\"a}hnig and J{\"o}rg T. Epplen and Scott Mayer},
  journal={The EMBO journal},
  year={1987},
  volume={6 12},
  pages={3647-53}
}
We have determined the amino acid sequence of the Ca2+-dependent cell adhesion molecule uvomorulin as it appears on the cell surface. The extracellular part of the molecule exhibits three internally repeated domains of 112 residues which are most likely generated by gene duplication. Each of the repeated domains contains two highly conserved units which could represent putative Ca2+-binding sites. Secondary structure predictions suggest that the putative Ca2+-binding units are located in… CONTINUE READING