The structure of bovine F1-ATPase inhibited by ADP and beryllium fluoride.

@article{Kagawa2004TheSO,
  title={The structure of bovine F1-ATPase inhibited by ADP and beryllium fluoride.},
  author={Reiko Kagawa and Martin G. Montgomery and Kerstin Braig and Andrew G. W. Leslie and John E Walker},
  journal={The EMBO journal},
  year={2004},
  volume={23 14},
  pages={2734-44}
}
The structure of bovine F1-ATPase inhibited with ADP and beryllium fluoride at 2.0 angstroms resolution contains two ADP.BeF3- complexes mimicking ATP, bound in the catalytic sites of the beta(TP) and beta(DP) subunits. Except for a 1 angstrom shift in the guanidinium of alphaArg373, the conformations of catalytic side chains are very similar in both sites. However, the ordered water molecule that carries out nucleophilic attack on the gamma-phosphate of ATP during hydrolysis is 2.6 angstroms… CONTINUE READING

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