The structure of beta-lactamases.

  title={The structure of beta-lactamases.},
  author={Richard P Ambler},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  volume={289 1036},
  • Richard P Ambler
  • Published 1980 in
    Philosophical transactions of the Royal Society…
The beta-lactamases are widely distributed in both Gram-positive and Gram-negative bacteria. They all inactivate penicillins and cephalosporins by opening the beta-lactam ring. Many varieties of the enzyme can be distinguished on the basis of their catalytic and molecular properties, but only amino acid sequence determination gives information upon which a molecular phylogeny can be based. The present evidence suggests that the beta-lactamases have a polyphyletic origin. All the beta-lactamases… CONTINUE READING
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