The structure of aconitase

@article{Robbins1989TheSO,
  title={The structure of aconitase},
  author={Arthur Robbins and Charles David Stout},
  journal={Proteins: Structure},
  year={1989},
  volume={5}
}
The crystal structure of the 80,000 Da FeS enzyme aconitase has been solved and refined at 2.1 Å resolution. The protein contains four domains; the first three from the N‐terminus are closely associated around the [3Fe–4S] cluster with all three cysteine ligands to the cluster being provided by the third domain. Associationof the larger C‐terminal domain with the first three domains createsan extensive cleft leading to the FeS cluster. Residues from all four domains contribute to the active… Expand
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The structure of activated pig heart aconitase [citrate(isocitrate) hydro-lyase, EC 4.2.1.3] containing a [4Fe-4S] cluster has been refined at 2.5-A resolution to a crystallographic residual ofExpand
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Native x-ray diffraction data from single crystals of inactive aconitase from pig heart have been collected on oscillation films to confirm the presence of a 3Fe center in the inactive form of ac onitase and provide crystallographic evidence that 3Fe clusters exhibit structural heterogeneity. Expand
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TLDR
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