The structure of a polyQ–anti-polyQ complex reveals binding according to a linear lattice model

@article{Li2007TheSO,
  title={The structure of a polyQ–anti-polyQ complex reveals binding according to a linear lattice model},
  author={Pingwei Li and Kathryn E Huey-Tubman and Tiyu Gao and Xiaojun Li and Anthony P. West and Melanie J. Bennett and Pamela J. Bjorkman},
  journal={Nature Structural &Molecular Biology},
  year={2007},
  volume={14},
  pages={381-387}
}
Huntington and related neurological diseases result from expansion of a polyglutamine (polyQ) tract. The linear lattice model for the structure and binding properties of polyQ proposes that both expanded and normal polyQ tracts in the preaggregation state are random-coil structures but that an expanded polyQ repeat contains a larger number of epitopes recognized by antibodies or other proteins. The crystal structure of polyQ bound to MW1, an antibody against polyQ, reveals that polyQ adopts an… CONTINUE READING
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