The structure of a mycobacterial outer-membrane channel.

  title={The structure of a mycobacterial outer-membrane channel.},
  author={Michael Faller and Michael Niederweis and Georg E. Schulz},
  volume={303 5661},
Mycobacteria have low-permeability outer membranes that render them resistant to most antibiotics. Hydrophilic nutrients can enter by way of transmembrane-channel proteins called porins. An x-ray analysis of the main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric goblet-like conformation with a single central channel. This is the first… CONTINUE READING