The structure of a membrane fusion mutant of the influenza virus haemagglutinin.

@article{Weis1990TheSO,
  title={The structure of a membrane fusion mutant of the influenza virus haemagglutinin.},
  author={William I Weis and Stephen Cusack and Jerry H. Brown and Rod S. Daniels and John J. Skehel and Don C. Wiley},
  journal={The EMBO journal},
  year={1990},
  volume={9 1},
  pages={17-24}
}
The haemagglutinin glycoprotein (HA) of influenza virus specifically mediates fusion of the viral and host cell endosomal membranes at the acidic pH of endosomes. The HAs from mutant viruses with raised fusion pH optima contain amino acid substitutions in regions of the HA structure thought to be involved in the fusion process [Daniels et al. (1985b) Cell, 40, 431-439]. We have determined the neutral pH crystal structure of one such mutant, HA2 112 Asp----Gly. A water molecule appears to… CONTINUE READING