The structure of a human type III Fcgamma receptor in complex with Fc.

@article{Radaev2001TheSO,
  title={The structure of a human type III Fcgamma receptor in complex with Fc.},
  author={Sergei Radaev and Stephanie Motyka and Wolf Herman Fridman and Catherine Saut{\`e}s-Fridman and Peter D. Sun},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 19},
  pages={16469-77}
}
Fcgamma receptors mediate antibody-dependent inflammatory responses and cytotoxicity as well as certain autoimmune dysfunctions. Here we report the crystal structure of a human Fc receptor (FcgammaRIIIB) in complex with an Fc fragment of human IgG1 determined from orthorhombic and hexagonal crystal forms at 3.0- and 3.5-A resolution, respectively. The refined structures from the two crystal forms are nearly identical with no significant discrepancies between the coordinates. Regions of the C… CONTINUE READING
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