The structure of Toho1 β‐lactamase in complex with penicillin reveals the role of Tyr105 in substrate recognition

Abstract

The role of the conserved residue Tyr105 in class A β-lactamases has been the subject of investigation using both structural studies and saturation mutagenesis. Both have shown that while it does not need to be strictly conserved for activity, it is important for substrate recognition. With this in mind we determined the crystal structure of Toho1… (More)
DOI: 10.1002/2211-5463.12132

4 Figures and Tables

Topics

  • Presentations referencing similar topics