The structure of Sky1p reveals a novel mechanism for constitutive activity

  title={The structure of Sky1p reveals a novel mechanism for constitutive activity},
  author={Brad J. Nolen and Chi Young Yun and Chung F. Wong and James Andrew McCammon and X Fu and Gourisankar Ghosh},
  journal={Nature Structural Biology},
Sky1p is the only member of the SR protein kinase (SRPK) family in Saccharomyces cerevisiae. SRPKs are constitutively active kinases that display remarkable substrate specificity and have been implicated in RNA processing. Here we present the three-dimensional structure of a fully active truncated Sky1p. Analysis of the structure and structure-based functional studies reveal that the C-terminal tail, an unusual Glu residue located in the P+1 loop, and a unique mechanism for the positioning of… CONTINUE READING

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