The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation.

@article{Barthe2010TheSO,
  title={The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation.},
  author={Philippe Barthe and Galina V. Mukamolova and Christian Roumestand and Martin Cohen-Gonsaud},
  journal={Structure},
  year={2010},
  volume={18 5},
  pages={606-15}
}
PknB is a transmembrane Ser/Thr protein kinase that defines and belongs to an ultraconserved kinase subfamily found in Gram-positive bacteria. Essential for Mycobacterium tuberculosis growth, its close homolog in Bacillus subtilis has been linked to exit from dormancy. The kinase possesses an extracellular region composed of a repetition of PASTA domains, believed to bind peptidoglycan fragments that might act as a signaling molecule. We report here the first solution structure of this… CONTINUE READING