The structure of Palau'amide, a potent cytotoxin from a species of the marine cyanobacterium Lyngbya.

@article{Williams2003TheSO,
  title={The structure of Palau'amide, a potent cytotoxin from a species of the marine cyanobacterium Lyngbya.},
  author={Philip G Williams and Wesley Y. Yoshida and Michael K Quon and Richard E. Moore and Valerie J Paul},
  journal={Journal of natural products},
  year={2003},
  volume={66 12},
  pages={1545-9}
}
Bioassay-guided fractionation of the extract of a species of Lyngbya from Palau has yielded Palau'amide (1), which had an IC(50) value of 13 nM against KB cells. The structure of 1 was elucidated by NMR analysis in a variety of solvents. In particular, a gradient-enhanced band-selective HMBC experiment allowed unambiguous assignment of HMBC correlations to carbon signals that were separated by 0.1 ppm. The relative stereochemistry and the absolute configurations of all but one (C-37) of the… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Marine bacterial sources of bioactive compounds.

Advances in food and nutrition research • 2012
View 2 Excerpts

Similar Papers

Loading similar papers…