The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.

@article{Pozzi2012TheSO,
  title={The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.},
  author={Cecilia Pozzi and Stefania Ferrari and Debora Cortesi and Rosaria Luciani and Robert Michael Stroud and Alessia Catalano and Maria Paola Costi and Stefano Mangani},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2012},
  volume={68 Pt 9},
  pages={1232-41}
}
Drug resistance to therapeutic antibiotics poses a challenge to the identification of novel targets and drugs for the treatment of infectious diseases. Infections caused by Enterococcus faecalis are a major health problem. Thymidylate synthase (TS) from E. faecalis is a potential target for antibacterial therapy. The X-ray crystallographic structure of E… CONTINUE READING