The structure of DNA within cationic lipid/DNA complexes.

@article{Braun2003TheSO,
  title={The structure of DNA within cationic lipid/DNA complexes.},
  author={Chad S Braun and Gouri S. Jas and Sirirat Choosakoonkriang and Gary S. Koe and Janet G. Smith and C. Russell Middaugh},
  journal={Biophysical journal},
  year={2003},
  volume={84 2 Pt 1},
  pages={1114-23}
}
The structure of DNA within CLDCs used for gene delivery is controversial. Previous studies using CD have been interpreted to indicate that the DNA is converted from normal B to C form in complexes. This investigation reexamines this interpretation using CD of model complexes, FTIR as well as Raman spectroscopy and molecular dynamics simulations to address this issue. CD spectra of supercoiled plasmid DNA undergo a significant loss of rotational strength in the signal near 275 nm upon… CONTINUE READING

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