The structure of "activation factor" for phosphofructokinase.

  title={The structure of "activation factor" for phosphofructokinase.},
  author={K. M. Uyeda and Etsuko Furuya and A Dean Sherry},
  journal={The Journal of biological chemistry},
  volume={256 16},
The "activation factor" for phosphofructokinase was shown by chemical analysis, by synthesis, and by 13C NMR spectroscopy to be beta-D-fructose-2,6-P2. This compound was prepared from D-fructose-1,2-cyclic 6-P2 by alkaline hydrolysis. D-Fructose-1,2-cyclic 6-P2 is ineffective in activating phosphofructokinase while synthetic D-fructose-2,6-P2 has the same specific activity toward phosphofructokinase as the "activation factor" isolated from rat liver, and it exhibits the same characteristics on… CONTINUE READING
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