The structure-function relationship of thrombin-like enzymes from the green pit viper (Trimeresurus albolabris).


Pit viper venoms can decrease fibrinogen levels in snakebite patients. Studies have shown that the hypofibrinogenemia is a consequence of snake venom thrombin-like enzymes (TLEs), the serine proteases that have the potential to be both diagnostic and therapeutic agents. Exosites of thrombin are the molecular regions that determine the substrate… (More)
DOI: 10.1016/j.toxicon.2015.04.005