The structure function of the death domain of human IRAK-M

  title={The structure function of the death domain of human IRAK-M},
  author={Jiangfeng Du and Gerry A. F. Nicolaes and Danielle Kruijswijk and Miranda V Versloot and Tom van der Poll and Cornelis van ’t Veer},
  booktitle={Cell Communication and Signaling},
IRAK-M is an inhibitor of Toll-like receptor signaling that acts by re-directing IRAK-4 activity to TAK1 independent NF-κB activation and by inhibition of IRAK-1/IRAK-2 activity. IRAK-M is expressed in monocytes/macrophages and lung epithelial cells. Lack of IRAK-M in mice greatly improves the resistance to nosocomial pneumonia and lung tumors, which entices IRAK-M as a potential therapeutic target. IRAK-M consists of an N-terminal death domain (DD), a dysfunctional kinase domain and… CONTINUE READING
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