The structure and replication of kinetoplast DNA.

  title={The structure and replication of kinetoplast DNA.},
  author={Theresa A. Shapiro and Paul T. Englund},
  journal={Annual review of microbiology},
The mitochondrial DNA of trypanosomatid protozoa, termed kinetoplast DNA (kDNA), is unique in its structure, function, and mode of replication. kDNA is a massive network, composed of thousands of topologically interlocked DNA circles, which resembles the chain mail of medieval armor. Each cell contains one network condensed into a disk-shaped structure within the matrix of its single mitochondrion. The kDNA circles are of two types, maxicircles present in a few dozen copies and minicircles… CONTINUE READING
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