The structure and regulation of vinculin.

@article{Ziegler2006TheSA,
  title={The structure and regulation of vinculin.},
  author={Wolfgang H. Ziegler and Robert C. Liddington and David R. Critchley},
  journal={Trends in cell biology},
  year={2006},
  volume={16 9},
  pages={
          453-60
        }
}
Vinculin is a ubiquitously expressed actin-binding protein frequently used as a marker for both cell-cell and cell-extracellular matrix (focal adhesion) adherens-type junctions, but its function has remained elusive. Vinculin is made up of a globular head linked to a tail domain by a short proline-rich sequence, and an intramolecular interaction between the head and tail masks the numerous ligand-binding sites in the protein. Determination of the crystal structure of vinculin has shed new light… CONTINUE READING

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