The structure and regulation of myotubularin phosphatases.

  title={The structure and regulation of myotubularin phosphatases.},
  author={Michael J Begley and Jack E. Dixon},
  journal={Current opinion in structural biology},
  volume={15 6},
The human neuromuscular diseases X-linked myotubular myopathy and Charcot-Marie-Tooth disease type 4B are caused by mutations in myotubularin family proteins. The myotubularins are a unique subfamily of protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as substrates. Recent structural studies, including the first crystal structure of a myotubularin family protein, have defined the structural features that are characteristic of the family and… CONTINUE READING
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