The structure and function of the glucagon-like peptide-1 receptor and its ligands.

@article{Donnelly2012TheSA,
  title={The structure and function of the glucagon-like peptide-1 receptor and its ligands.},
  author={Dan Donnelly},
  journal={British journal of pharmacology},
  year={2012},
  volume={166 1},
  pages={27-41}
}
Glucagon-like peptide-1(7-36)amide (GLP-1) is a 30-residue peptide hormone released from intestinal L cells following nutrient consumption. It potentiates the glucose-induced secretion of insulin from pancreatic beta cells, increases insulin expression, inhibits beta-cell apoptosis, promotes beta-cell neogenesis, reduces glucagon secretion, delays gastric emptying, promotes satiety and increases peripheral glucose disposal. These multiple effects have generated a great deal of interest in the… CONTINUE READING

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