The structure and function of the ATP-sensitive K + channel in insulin-secreting pancreatic â-cells

@inproceedings{Miki1999TheSA,
  title={The structure and function of the ATP-sensitive K + channel in insulin-secreting pancreatic {\^a}-cells},
  author={Toru Miki and Koji Nagashima and Susumu Seino},
  year={1999}
}
ATP-sensitive K channels (KATP channels) play important roles in many cellular functions by coupling cell metabolism to electrical activity. The KATP channels in pancreatic â-cells are thought to be critical in the regulation of glucose-induced and sulfonylurea-induced insulin secretion. Until recently, however, the molecular structure of the KATP channel was not known. Cloning members of the novel inwardly rectifying K channel subfamily Kir6·0 (Kir6·1 and Kir6·2) and the sulfonylurea receptors… CONTINUE READING

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