The structure and function of telomerase reverse transcriptase.

  title={The structure and function of telomerase reverse transcriptase.},
  author={Chantal Autexier and Neal F Lue},
  journal={Annual review of biochemistry},
The structure and integrity of telomeres are essential for genome stability. Telomere dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The maintenance of telomere repeats in most eukaryotic organisms requires telomerase, which consists of a reverse transcriptase (RT) and an RNA template that dictates the synthesis of the G-rich strand of telomere terminal repeats. Structurally, telomerase reverse transcriptase (TERT) contains unique and variable N- and C… CONTINUE READING
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