The structure and function of proline recognition domains.

  title={The structure and function of proline recognition domains.},
  author={Ali Zarrinpar and Roby P. Bhattacharyya and Wendell A Lim},
  journal={Science's STKE : signal transduction knowledge environment},
  volume={2003 179},
One particularly abundant group of modular recognition domains consists of those that bind proline-rich motifs. Such modules, including the SH3, WW, and EVH1 domains, play a critical role in the assembly and regulation of many intracellular signaling complexes. These domains use strikingly similar molecular mechanisms of proline recognition. We discuss some of the potential biological advantages conferred by proline recognition, which may explain its widespread use in signaling. 
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A high - affinity ArgXXLys SH 3 binding motif confers specificity for the interaction between Gads and SLP76 in T cell signaling

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