The structure and function of platelet integrins.

@article{Bennett2009TheSA,
  title={The structure and function of platelet integrins.},
  author={Joel S. Bennett and B. W. Berger and Paul C Billings},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2009},
  volume={7 Suppl 1},
  pages={200-5}
}
Integrins are a ubiquitous family of non-covalently associated alpha/beta transmembrane heterodimers linking extracellular ligands to intracellular signaling pathways [1] [Cell, 2002; 110: 673]. Platelets contain five integrins, three beta1 integrins that mediate platelet adhesion to the matrix proteins collagen, fibronectin and laminin, and the beta3 integrins alphavbeta3 and alphaIIbbeta3 [2] [J Clin Invest, 2005; 115: 3363]. While there are only several hundred alphavbeta3 molecules per… CONTINUE READING

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