The structure and function of platelet integrins.

  title={The structure and function of platelet integrins.},
  author={Joel S. Bennett and B. W. Berger and Paul C Billings},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={7 Suppl 1},
Integrins are a ubiquitous family of non-covalently associated alpha/beta transmembrane heterodimers linking extracellular ligands to intracellular signaling pathways [1] [Cell, 2002; 110: 673]. Platelets contain five integrins, three beta1 integrins that mediate platelet adhesion to the matrix proteins collagen, fibronectin and laminin, and the beta3 integrins alphavbeta3 and alphaIIbbeta3 [2] [J Clin Invest, 2005; 115: 3363]. While there are only several hundred alphavbeta3 molecules per… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 56 extracted citations


Publications referenced by this paper.
Showing 1-10 of 75 references

A conserved transmembrane domain interface regulated integrin function

BW Berger, L Span, +4 authors JS Bennett
Blood • 2008

Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces

LuoBH ZhuJ, ZhangC XiaoT, SpringerTA NishidaN
Mol Cell • 2008

Similar Papers

Loading similar papers…