The structure and function of Francisella lipopolysaccharide.

  title={The structure and function of Francisella lipopolysaccharide.},
  author={John S Gunn and Robert K Ernst},
  journal={Annals of the New York Academy of Sciences},
A key factor in the biology of Francisella spp. is lipopolysaccharide (LPS). Francisella LPS has many unique structural properties and poorly activates proinflammatory responses due to its lack of interaction with toll-like receptor 4 (TLR4). The LPS of this organism can be modified by various carbohydrates including glucose, mannose and galactosamine, which affect various aspects of virulence. Spontaneously occurring colony variants of F. tularensis have altered LPS. This altered LPS may… CONTINUE READING