The structure and function of ‘active zone material’ at synapses

  title={The structure and function of ‘active zone material’ at synapses},
  author={Joseph A. Szule and Jae Hoon Jung and Uel Jackson McMahan},
  journal={Philosophical Transactions of the Royal Society B: Biological Sciences},
The docking of synaptic vesicles on the presynaptic membrane and their priming for fusion with it to mediate synaptic transmission of nerve impulses typically occur at structurally specialized regions on the membrane called active zones. Stable components of active zones include aggregates of macromolecules, ‘active zone material’ (AZM), attached to the presynaptic membrane, and aggregates of Ca2+-channels in the membrane, through which Ca2+ enters the cytosol to trigger impulse-evoked vesicle… 

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