The structure and enzymic activities of the C1r and C1s subcomponents of C1, the first component of human serum complement.

@article{Sim1977TheSA,
  title={The structure and enzymic activities of the C1r and C1s subcomponents of C1, the first component of human serum complement.},
  author={Robert B Sim and Rodney R. Porter and Kenneth B. M. Reid and I Giovanni Gigli},
  journal={The Biochemical journal},
  year={1977},
  volume={163 2},
  pages={219-27}
}
The subcomponents C1r and C1s and their activated forms C-1r and C-1s were each found to have mol.wts. in dissociating solvents of about 83000. The amino acid compositions of each were similar, but there were significant differences in the monosaccharide analyses of subcomponents C1r and C1s, whether activated or not. Subcomponents C1r and C1s have only one polypeptide chain, but subcomponents C-1r and C-1s each contain two peptide chains of approx. mol.wts. 56000 ("a" chain) and 27000 ("b… CONTINUE READING