The structure and conformational behavior of sulfonium salt glycosidase inhibitors in solution: a combined quantum mechanical NMR approach.

@article{GonzlezOuteirio2004TheSA,
  title={The structure and conformational behavior of sulfonium salt glycosidase inhibitors in solution: a combined quantum mechanical NMR approach.},
  author={Jorge Gonz{\'a}lez-Outeiri{\~n}o and John G. Glushka and Aloysius H Siriwardena and Robert J. Woods},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 22},
  pages={6866-7}
}
We present the conformational analysis of an inhibitor of alpha-mannosidase, based on a novel sulfonium salt structure (1) that mimics the mannosyl cation intermediate. Because of the number of possible isomeric structures for 1, as well as its complex molecular structure, traditional conformational analysis by NMR was not applicable. Instead, a single… CONTINUE READING