The structure and assembly dynamics of plasmid actin AlfA imply a novel mechanism of DNA segregation.

@article{Polka2009TheSA,
  title={The structure and assembly dynamics of plasmid actin AlfA imply a novel mechanism of DNA segregation.},
  author={Jessica K Polka and Justin M Kollman and David A. Agard and R Dyche Mullins},
  journal={Journal of bacteriology},
  year={2009},
  volume={191 20},
  pages={6219-30}
}
Bacterial cytoskeletal proteins participate in a variety of processes, including cell division and DNA segregation. Polymerization of one plasmid-encoded, actin-like protein, ParM, segregates DNA by pushing two plasmids in opposite directions and forms the current paradigm for understanding active plasmid segregation. An essential feature of ParM assembly is its dynamically instability, the stochastic switching between growth and disassembly. It is unclear whether dynamic instability is an… CONTINUE READING

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