The structure, organization and differential expression of the rat gene encoding biliverdin reductase.

@article{McCoubrey1995TheSO,
  title={The structure, organization and differential expression of the rat gene encoding biliverdin reductase.},
  author={William K. McCoubrey and M A Cooklis and Mahin D. Maines},
  journal={Gene},
  year={1995},
  volume={160 2},
  pages={
          235-40
        }
}
Screening of phage lambda libraries and genomic polymerase chain reactions were employed to generate clones of the rat gene encoding biliverdin reductase (BVR), the penultimate enzyme in the heme metabolic pathway. This enzyme, which converts biliverdin to bilirubin, is unique among enzymes characterized to date in that it exhibits two pH optima, 6.75 and 8.7, and utilizes a different cofactor, NADH and NADPH, respectively, at each optimum. The gene, which is 12270 bp in length, consists of… CONTINUE READING
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