The structurally related auxin and melatonin tryptophan-derivatives and their roles in Arabidopsis thaliana and in the human malaria parasite Plasmodium falciparum.

@article{Koyama2013TheSR,
  title={The structurally related auxin and melatonin tryptophan-derivatives and their roles in Arabidopsis thaliana and in the human malaria parasite Plasmodium falciparum.},
  author={F C Koyama and Thais L G Carvalho and Eduardo Alves and Henrique Borges da Silva and Mauro Ferreira de Azevedo and Adriana Silva Hemerly and C{\'e}lia Regina da Silva Garcia},
  journal={The Journal of eukaryotic microbiology},
  year={2013},
  volume={60 6},
  pages={646-51}
}
Indole compounds are involved in a range of functions in many organisms. In the human malaria parasite Plasmodium falciparum, melatonin and other tryptophan derivatives are able to modulate its intraerythrocytic cycle, increasing the schizont population as well as parasitemia, likely through ubiquitin-proteasome system (UPS) gene regulation. In plants, melatonin regulates root development, in a similar way to that described for indoleacetic acid, suggesting that melatonin and indoleacetic acid… CONTINUE READING
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