The structural impact of a polyglutamine tract is location-dependent.

@article{Robertson2008TheSI,
  title={The structural impact of a polyglutamine tract is location-dependent.},
  author={Amy L. Robertson and James A. Horne and Andrew M Ellisdon and Bronwen K Thomas and Martin J Scanlon and Stephen P. Bottomley},
  journal={Biophysical journal},
  year={2008},
  volume={95 12},
  pages={5922-30}
}
Polyglutamine (polyQ) expansion leads to protein aggregation and neurodegeneration in Huntington's disease and eight other inherited neurological conditions. Expansion of the polyQ tract beyond a threshold of 37 glutamines leads to the formation of toxic nuclear aggregates. This suggests that polyQ expansion causes a conformational change within the protein, the nature of which is unclear. There is a trend in the disease proteins that the polyQ tract is located external to but not within a… CONTINUE READING

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