The structural gene for the mitochondrial aldehyde dehydrogenase maps to human chromosome 12

@article{Braun2004TheSG,
  title={The structural gene for the mitochondrial aldehyde dehydrogenase maps to human chromosome 12},
  author={Thomas Braun and Karl Heinz Grzeschik and Eva Bober and S. Singh and Dharam P. Agarwal and Heinz Werner Goedde},
  journal={Human Genetics},
  year={2004},
  volume={73},
  pages={365-367}
}
SummaryA cloned 850 bp cDNA fragment corresponding to the 3′-coding part of human ALDHI-mRNA was used as a probe for the chromosomal assignment of the ALDHI gene. Southern blot analysis of human-rodent somatic cell hybrids indicates that the human ALDHI gene resides on chromosome 12. 

Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes γ-aminobutyraldehyde

A cDNA clone of the E3 isozyme of human liver aldehyde dehydrogenase consisting of a 1320-base pair (bp) coding region and a 180-bp non-coding region at the 3′ end was used for chromosomal

Origin and dispersal of atypical aldehyde dehydrogenase ALDH2487Lys.

Genetisch bedingte Variabilität des Alkoholstoffwechsels und ihr Einfluß auf Trinkverhalten und Neigung zum Alkoholismus

People sensitive to alcohol by virtue of their genetically controlled ALDH isozyme deficiency may be discouraged from drinking large amounts of alcohol in their daily life due to the initial adverse reaction experienced after drinking alcohol.

References

SHOWING 1-10 OF 14 REFERENCES

Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2.

The degree of homology between human ALDH1 and ALDH2 is 66% for the coding regions of their cDNAs and 69% at the protein level and no significant homology was found in their 3' untranslated regions.

Chromosome assignment, biochemical and immunological studies on a human aldehyde dehydrogenase, ALDH3

The biochemical properties of ALDH isozymes have been examined in human tissues and one set, designated ALDH3, has been studied in detail, and high levels of expression were found in human‐rodent hybrids, constructed using rat hepatoma cells, and these hybrids were used to assign the human AL DH3 gene to chromosome 17.

Biochemical genetics of aldehyde dehydrogenase isozymes in the mouse: Evidence for stomach- and testis-specific isozymes

This study provides evidence for six genetic loci for this enzyme, identified in combination with previous investigations on mouse aldehyde dehydrogenases, that are distinct but closely linked loci on the mouse genome.

Isolation and subregional mapping of a human cDNA clone detecting a common RELP on chromosome 12

cDNA libraries are a potential source of DNA probes which can be used to screen for restriction fragment length polymorphisms (RFLPs) and it is shown that they can be a fruitful source for such probes.

Aldehyde dehydrogenase from human liver. Primary structure of the cytoplasmic isoenzyme.

Analysis of CNBr fragments and other peptides from human liver cytoplasmic aldehyde dehydrogenase enabled determination of the complete primary structure of this protein, supporting the concept that the enzyme is a homotetramer.

Construction of a new family of high efficiency bacterial expression vectors: identification of cDNA clones coding for human liver proteins.

The cloning of albumin and complement C9 genes from a human cDNA library using polyclonal and monoclonal antibodies is described, allowing antibodies of pre‐determined specificity to be made against expressed regions of cloned DNA.

Aldehyde dehydrogenase from human liver

Analysis of CNBr fragments and other peptides from human liver cytoplasmic aldehyde dehydrogenase enabled determination of the complete primary structure of this protein, supporting the concept that the enzyme is a homotetramer.

The role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes in alcohol metabolism, alcohol sensitivity, and alcoholism.

It is demonstrated that the isozymes of ALDH may play an important role in the pathogenesis of alcohol-related organ damage and in the biological sensitivity to alcohol in certain ethnic groups.

Isola - tion and subregional mapping of a human cDNA clone detecting a common RFLP on chromosome 12

  • Hum Genet
  • 1984