The structural biology of Toll-like receptors.

  title={The structural biology of Toll-like receptors.},
  author={Istvan Botos and David M. Segal and David Rhodri Davies},
  volume={19 4},
The membrane-bound Toll-like receptors (TLRs) trigger innate immune responses after recognition of a wide variety of pathogen-derived compounds. Despite the wide range of ligands recognized by TLRs, the receptors share a common structural framework in their extracellular, ligand-binding domains. These domains all adopt horseshoe-shaped structures built from leucine-rich repeat motifs. Typically, on ligand binding, two extracellular domains form an "m"-shaped dimer sandwiching the ligand… CONTINUE READING
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