The structural basis of water permeation and proton exclusion in aquaporins (Review)

@article{Fu2007TheSB,
  title={The structural basis of water permeation and proton exclusion in aquaporins (Review)},
  author={Dax Fu and Min Lu},
  journal={Molecular Membrane Biology},
  year={2007},
  volume={24},
  pages={366 - 374}
}
  • D. Fu, M. Lu
  • Published 1 January 2007
  • Chemistry, Medicine
  • Molecular Membrane Biology
Aquaporins (AQPs) represent a ubiquitous class of integral membrane proteins that play critical roles in cellular osmoregulations in microbes, plants and mammals. AQPs primarily function as water-conducting channels, whereas members of a sub-class of AQPs, termed aquaglyceroporins, are permeable to small neutral solutes such as glycerol. While AQPs facilitate transmembrane permeation of water and/or small neutral solutes, they preclude the conduction of protons. Consequently, openings of AQP… Expand
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