The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer

Abstract

Aim:Dominant negative mutant G proteins have provided critical insight into the mechanisms of G protein-coupled receptor (GPCR) signaling, but the mechanisms underlying the dominant negative characteristics are not completely understood. The aim of this study was to determine the structure of the dominant negative Gαi1β1γ2 G203A/A326S complex (Gi-DN) and to… (More)
DOI: 10.1038/aps.2016.69

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