The structural basis of the Tle4-Tli4 complex reveals the self-protection mechanism of H2-T6SS in Pseudomonas aeruginosa.

@article{Lu2014TheSB,
  title={The structural basis of the Tle4-Tli4 complex reveals the self-protection mechanism of H2-T6SS in Pseudomonas aeruginosa.},
  author={Defen Lu and Youshi Zheng and Naishun Liao and Ling Wei and Bo Xu and Xiaolong Liu and Jingfeng Liu},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2014},
  volume={70 Pt 12},
  pages={3233-43}
}
The type VI secretion system (T6SS) has recently been demonstrated to mediate interbacterial competition and to discriminate between self and nonself. T6SS(+) bacteria employ toxic effectors to inhibit rival cells and concurrently use effector cognate immunity proteins to protect their sibling cells. The effector and immunity pairs (E-I pairs) endow the bacteria with a great advantage in niche competition. Tle4-Tli4 (PA1510-PA1509) is a newly identified E-I pair that is controlled by H2-T6SS in… CONTINUE READING

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