The structural basis of ribozyme-catalyzed RNA assembly.

@article{Robertson2007TheSB,
  title={The structural basis of ribozyme-catalyzed RNA assembly.},
  author={Michael P. Robertson and William G Scott},
  journal={Science},
  year={2007},
  volume={315 5818},
  pages={1549-53}
}
Life originated, according to the RNA World hypothesis, from self-replicating ribozymes that catalyzed ligation of RNA fragments. We have solved the 2.6 angstrom crystal structure of a ligase ribozyme that catalyzes regiospecific formation of a 5' to 3' phosphodiester bond between the 5'-triphosphate and the 3'-hydroxyl termini of two RNA fragments. Invariant residues form tertiary contacts that stabilize a flexible stem of the ribozyme at the ligation site, where an essential magnesium ion… CONTINUE READING
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