The structural basis of ribosome activity in peptide bond synthesis.

@article{Nissen2000TheSB,
  title={The structural basis of ribosome activity in peptide bond synthesis.},
  author={P. Nissen and J. Hansen and N. Ban and P. Moore and T. Steitz},
  journal={Science},
  year={2000},
  volume={289 5481},
  pages={
          920-30
        }
}
Using the atomic structures of the large ribosomal subunit from Haloarcula marismortui and its complexes with two substrate analogs, we establish that the ribosome is a ribozyme and address the catalytic properties of its all-RNA active site. Both substrate analogs are contacted exclusively by conserved ribosomal RNA (rRNA) residues from domain V of 23S rRNA; there are no protein side-chain atoms closer than about 18 angstroms to the peptide bond being synthesized. The mechanism of peptide bond… Expand
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