The structural basis of differential DNA sequence recognition by restriction–modification controller proteins

@inproceedings{Ball2012TheSB,
  title={The structural basis of differential DNA sequence recognition by restriction–modification controller proteins},
  author={Neil J. Ball and John E McGeehan and Simon D. Streeter and S.-J. Thresh and G. Geoff Kneale},
  booktitle={Nucleic acids research},
  year={2012}
}
Controller (C) proteins regulate the expression of restriction-modification (RM) genes in a wide variety of RM systems. However, the RM system Esp1396I is of particular interest as the C protein regulates both the restriction endonuclease (R) gene and the methyltransferase (M) gene. The mechanism of this finely tuned genetic switch depends on differential binding affinities for the promoters controlling the R and M genes, which in turn depends on differential DNA sequence recognition and the… CONTINUE READING