The structural basis of allosteric regulation in proteins.

  title={The structural basis of allosteric regulation in proteins.},
  author={Roman A. Laskowski and Fabian Gerick and Janet M. Thornton},
  journal={FEBS letters},
  volume={583 11},
Allosteric regulation of protein function occurs when the regulatory trigger, such as the binding of a small-molecule effector or inhibitor, takes place some distance from the protein's, or protein complex's, active site. This distance can be a few A, or tens of A. Many proteins are regulated in this way and exhibit a variety of allosteric mechanisms. Here we review how analyses of experimentally determined models of protein 3D structures, using either X-ray crystallography or NMR spectroscopy… CONTINUE READING

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