The structural basis of T cell activation by superantigens.


Superantigens (SAGs) are a class of immunostimulatory and disease-causing proteins of bacterial or viral origin with the ability to activate large fractions (5-20%) of the T cell population. Activation requires simultaneous interaction of the SAG with the V beta domain of the T cell receptor (TCR) and with major histocompatibility complex (MHC) class II… (More)


Cite this paper

@article{Li1999TheSB, title={The structural basis of T cell activation by superantigens.}, author={Hongqi Li and A. Llera and Emilio L Malchiodi and Roy A. Mariuzza}, journal={Annual review of immunology}, year={1999}, volume={17}, pages={435-66} }