The structural basis of CstF-77 modulation of cleavage and polyadenylation through stimulation of CstF-64 activity

@inproceedings{Grozdanov2018TheSB,
  title={The structural basis of CstF-77 modulation of cleavage and polyadenylation through stimulation of CstF-64 activity},
  author={Petar N. Grozdanov and Elahe Masoumzadeh and Michael P Latham and Clinton C MacDonald},
  booktitle={Nucleic acids research},
  year={2018}
}
Cleavage and polyadenylation (C/P) of mRNA is an important cellular process that promotes increased diversity of mRNA isoforms and could change their stability in different cell types. The cleavage stimulation factor (CstF) complex, part of the C/P machinery, binds to U- and GU-rich sequences located downstream from the cleavage site through its RNA-binding subunit, CstF-64. Less is known about the function of the other two subunits of CstF, CstF-77 and CstF-50. Here, we show that the carboxy… CONTINUE READING
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